Beilstein J. Org. Chem.2019,15, 1210–1216, doi:10.3762/bjoc.15.118
polyfurfurylalcohol-supported catalysts for applications in heterogeneous enamine catalysis. The utilization of the polymer-supported catalysts in both batch and continuous-flow organocatalytic procedures proved moderate catalytic efficacy and enantioselectivity, but excellent diastereoselectivity in the
; multicomponent reactions; organocatalysis; polyfurfurylalcohol; Introduction
The immobilization of secondary amine-based catalysts onto organic polymers and silica gel has emerged as an effective strategy that combines the power of heterogeneous and organocatalysis [1][2][3]. Asymmetric catalysis using polymer
., polystyrene) [1][2][3]. When aiming at implementing large-scale catalytic processes with supported organocatalysts, a relevant “green” premise is the use of renewable and readily available solid supports [1][2][3][4][5]. Accordingly, we envisioned the utilization of the polymer polyfurfurylalcohol (PFA
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Graphical Abstract
Scheme 1:
Schematic synthesis of polyfurfulyl alcohol (PFA) incorporating a prolyl peptide catalyst. AA: Amin...